Olfaction: from odorant molecules to the olfactory cortex.
نویسندگان
چکیده
How do we smell? Our knowledge of how odor information from the environment is perceived has greatly advanced since the discovery of approximately 1,000 genes for odorant receptors in the mammalian genome. From the combination of molecular-genetic, electrophysiological, and optical imaging studies a better understanding of how we smell is emerging.
منابع مشابه
Recent concepts about sense of smell, odorant receptors and physiology of olfaction- an insight
The sense of olfaction reached its zenith in development much earlier than other special senses. Olfaction is much more acute than the other senses, exhibits both high sensitivity for odours and high discrimination between them. This plays a very important role even in the social and behavioral aspects of human beings. Recent studies using molecular genetics, electrophysiology and behavioral an...
متن کاملDissociated representations of irritation and valence in human primary olfactory cortex.
Irritation and negative valence are closely associated in perception. However, these perceptual aspects can be dissociated in olfaction where irritation can accompany both pleasant and unpleasant odorants. Whereas the sensation of odor reflects transduction at olfactory receptors, irritation reflects concurrent transduction of the odorant at trigeminal receptors. Thus a stimulus can be either a...
متن کاملSNIFFING OUT SMELL: Odorant Detection, Coding, and Perception
Smell, the most ancient of all senses, is crucial for animal reproduction and survival. Humans can detect the most minute changes in odorant structures as a different perceived odor. Despite its significance, the mechanism of olfactory sensory perception remained unknown before 1991. Through research in my lab and others, we discovered a large multigene family containing approximately 1000 gene...
متن کاملAnatomical contributions to odorant sampling and representation in rodents: zoning in on sniffing behavior.
Odorant sampling behaviors such as sniffing bring odorant molecules into contact with olfactory receptor neurons (ORNs) to initiate the sensory mechanisms of olfaction. In rodents, inspiratory airflow through the nose is structured and laminar; consequently, the spatial distribution of adsorbed odorant molecules during inspiration is predictable. Physicochemical properties such as water solubil...
متن کاملThalamic olfaction: characterizing odor processing in the mediodorsal thalamus of the rat.
Thalamus is a key crossroad structure involved in various functions relative to visual, auditory, gustatory, and somatosensory senses. Because of the specific organization of the olfactory pathway (i.e., no direct thalamic relay between sensory neurons and primary cortex), relatively little attention has been directed toward the thalamus in olfaction. However, an olfactory thalamus exists: the ...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
عنوان ژورنال:
- News in physiological sciences : an international journal of physiology produced jointly by the International Union of Physiological Sciences and the American Physiological Society
دوره 19 شماره
صفحات -
تاریخ انتشار 2004